CLUW's National Office is located in Washington, DC and is directed by the National President. The National Staff consists of an Executive Director and a Field and Membership Organizer.

Its governing body consists of a National Officers Council, composed of 19 women union leaders, CLUW's Presidents Emeritae, General Counsel, and a National Executive Board (NEB) elected at CLUW's Biennial Convention.

CLUW's National President is Karen See of the American Postal Workers Union.

The National Officers Council is representative of members from a diverse crosssection of unions within the organization. The council meets at least six times annually to act on business between Executive Board meetings and Conventions.

The National Executive Board (NEB) includes members of the National Officers Council, State Presidents, Chapter Presidents, Union Delegates and Chapter Delegates. Union and chapter delegates are elected in proportion to their membership in CLUW. Board meetings are held three times per year. Educational conferences are usually held the day preceding each NEB meeting.

The NEB maintains Standing Committees in the following areas: Affirmative Action, Archives, Constitution, CLUW Elections, Family Issues, Finance, Minority Issues, New Technologies, Legislative, Mature Women Workers, Organizing the Unorganized, Women in Non-Traditional Jobs, Media Recruitment, Women in Union Leadership. Task Forces are maintained on Women's Health Issues, Violence Against Women and Young Women Workers.

The CLUW Center for Education & Research located at the National CLUW office was established in 1979 as a separate non-profit, tax-exempt entity of CLUW. The Center was established to provide the necessary tools for union and CLUW members to become effective advocates for working women in the workplace and the labor movement.